6‐Hydroxydopamine‐induced alterations in blood–brain barrier permeability
Identifieur interne : 001549 ( Main/Exploration ); précédent : 001548; suivant : 0015506‐Hydroxydopamine‐induced alterations in blood–brain barrier permeability
Auteurs : P. M. Carvey [États-Unis] ; C. H. Zhao [États-Unis] ; B. Hendey [États-Unis] ; H. Lum [États-Unis] ; J. Trachtenberg [États-Unis] ; B. S. Desai [États-Unis] ; J. Snyder [États-Unis] ; Y. G. Zhu [États-Unis] ; Z. D. Ling [États-Unis]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2005-09.
English descriptors
- KwdEn :
Abstract
Vascular inflammation is well known for its ability to compromise the function of the blood–brain barrier (BBB). Whether inflammation on the parenchymal side of the barrier, such as that associated with Parkinson's‐like dopamine (DA) neuron lesions, similarly disrupts BBB function, is unknown. We assessed BBB integrity by examining the leakage of FITC‐labeled albumin or horseradish peroxidase from the vasculature into parenchyma in animals exposed to the DA neurotoxin 6‐hydroxydopamine (6OHDA). Unilateral injections of 6OHDA into the striatum or the medial forebrain bundle produced increased leakage in the ipsilateral substantia nigra and striatum 10 and 34 days following 6OHDA. Microglia were markedly activated and DA neurons were reduced by the lesions. The areas of BBB leakage were associated with increased expression of P‐glycoprotein and β3‐integrin expression suggesting, respectively, a compensatory response to inflammation and possible angiogenesis. Behavioural studies revealed that domperidone, a DA antagonist that normally does not cross the BBB, attenuated apomorphine‐induced stereotypic behaviour in animals with 6OHDA lesions. This suggests that drugs which normally have no effect in brain can enter following Parkinson‐like lesions. These data suggest that the events associated with DA neuron loss compromise BBB function.
Url:
DOI: 10.1111/j.1460-9568.2005.04281.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">6‐Hydroxydopamine‐induced alterations in blood–brain barrier permeability</title><author><name sortKey="Carvey, P M" sort="Carvey, P M" uniqKey="Carvey P" first="P. M." last="Carvey">P. M. Carvey</name></author><author><name sortKey="Zhao, C H" sort="Zhao, C H" uniqKey="Zhao C" first="C. H." last="Zhao">C. H. Zhao</name></author><author><name sortKey="Hendey, B" sort="Hendey, B" uniqKey="Hendey B" first="B." last="Hendey">B. Hendey</name></author><author><name sortKey="Lum, H" sort="Lum, H" uniqKey="Lum H" first="H." last="Lum">H. Lum</name></author><author><name sortKey="Trachtenberg, J" sort="Trachtenberg, J" uniqKey="Trachtenberg J" first="J." last="Trachtenberg">J. Trachtenberg</name></author><author><name sortKey="Desai, B S" sort="Desai, B S" uniqKey="Desai B" first="B. S." last="Desai">B. S. Desai</name></author><author><name sortKey="Snyder, J" sort="Snyder, J" uniqKey="Snyder J" first="J." last="Snyder">J. Snyder</name></author><author><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name></author><author><name sortKey="Ling, Z D" sort="Ling, Z D" uniqKey="Ling Z" first="Z. D." last="Ling">Z. D. Ling</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1B9A282D467AB3F55848B39C4EB7CC58A62864E9</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1111/j.1460-9568.2005.04281.x</idno><idno type="url">https://api.istex.fr/document/1B9A282D467AB3F55848B39C4EB7CC58A62864E9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002903</idno><idno type="wicri:Area/Main/Curation">002555</idno><idno type="wicri:Area/Main/Exploration">001549</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">6‐Hydroxydopamine‐induced alterations in blood–brain barrier permeability</title><author><name sortKey="Carvey, P M" sort="Carvey, P M" uniqKey="Carvey P" first="P. M." last="Carvey">P. M. Carvey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zhao, C H" sort="Zhao, C H" uniqKey="Zhao C" first="C. H." last="Zhao">C. H. Zhao</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hendey, B" sort="Hendey, B" uniqKey="Hendey B" first="B." last="Hendey">B. Hendey</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Lum, H" sort="Lum, H" uniqKey="Lum H" first="H." last="Lum">H. Lum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Trachtenberg, J" sort="Trachtenberg, J" uniqKey="Trachtenberg J" first="J." last="Trachtenberg">J. Trachtenberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Desai, B S" sort="Desai, B S" uniqKey="Desai B" first="B. S." last="Desai">B. S. Desai</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Snyder, J" sort="Snyder, J" uniqKey="Snyder J" first="J." last="Snyder">J. Snyder</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Ling, Z D" sort="Ling, Z D" uniqKey="Ling Z" first="Z. D." last="Ling">Z. D. Ling</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush University Medical Center, Department of Pharmacology, 1735 West Harrison Street, Cohn 406, Chicago, IL 60612</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neuroscience</title><idno type="ISSN">0953-816X</idno><idno type="eISSN">1460-9568</idno><imprint><publisher>Blackwell Science Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-09">2005-09</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1158">1158</biblScope><biblScope unit="page" to="1168">1168</biblScope></imprint><idno type="ISSN">0953-816X</idno></series><idno type="istex">1B9A282D467AB3F55848B39C4EB7CC58A62864E9</idno><idno type="DOI">10.1111/j.1460-9568.2005.04281.x</idno><idno type="ArticleID">EJN4281</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0953-816X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson</term><term>inflammation</term><term>microglia</term><term>neurodegeneration</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vascular inflammation is well known for its ability to compromise the function of the blood–brain barrier (BBB). Whether inflammation on the parenchymal side of the barrier, such as that associated with Parkinson's‐like dopamine (DA) neuron lesions, similarly disrupts BBB function, is unknown. We assessed BBB integrity by examining the leakage of FITC‐labeled albumin or horseradish peroxidase from the vasculature into parenchyma in animals exposed to the DA neurotoxin 6‐hydroxydopamine (6OHDA). Unilateral injections of 6OHDA into the striatum or the medial forebrain bundle produced increased leakage in the ipsilateral substantia nigra and striatum 10 and 34 days following 6OHDA. Microglia were markedly activated and DA neurons were reduced by the lesions. The areas of BBB leakage were associated with increased expression of P‐glycoprotein and β3‐integrin expression suggesting, respectively, a compensatory response to inflammation and possible angiogenesis. Behavioural studies revealed that domperidone, a DA antagonist that normally does not cross the BBB, attenuated apomorphine‐induced stereotypic behaviour in animals with 6OHDA lesions. This suggests that drugs which normally have no effect in brain can enter following Parkinson‐like lesions. These data suggest that the events associated with DA neuron loss compromise BBB function.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Carvey, P M" sort="Carvey, P M" uniqKey="Carvey P" first="P. M." last="Carvey">P. M. Carvey</name></region><name sortKey="Desai, B S" sort="Desai, B S" uniqKey="Desai B" first="B. S." last="Desai">B. S. Desai</name><name sortKey="Hendey, B" sort="Hendey, B" uniqKey="Hendey B" first="B." last="Hendey">B. Hendey</name><name sortKey="Ling, Z D" sort="Ling, Z D" uniqKey="Ling Z" first="Z. D." last="Ling">Z. D. Ling</name><name sortKey="Lum, H" sort="Lum, H" uniqKey="Lum H" first="H." last="Lum">H. Lum</name><name sortKey="Snyder, J" sort="Snyder, J" uniqKey="Snyder J" first="J." last="Snyder">J. Snyder</name><name sortKey="Trachtenberg, J" sort="Trachtenberg, J" uniqKey="Trachtenberg J" first="J." last="Trachtenberg">J. Trachtenberg</name><name sortKey="Zhao, C H" sort="Zhao, C H" uniqKey="Zhao C" first="C. H." last="Zhao">C. H. Zhao</name><name sortKey="Zhu, Y G" sort="Zhu, Y G" uniqKey="Zhu Y" first="Y. G." last="Zhu">Y. G. Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001549 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001549 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1B9A282D467AB3F55848B39C4EB7CC58A62864E9
|texte= 6‐Hydroxydopamine‐induced alterations in blood–brain barrier permeability
}}
| This area was generated with Dilib version V0.6.23. |  |